The Western Pacific-South China Sea-East Indian Ocean (two oceans and one sea) region has an important impact on the weather and climate, national security, as well as social economy of China. However, due to the limitation of data conditions, the existing research on high sea winds are mainly focused on the offshore, resulting in the insufficient understanding of the temporal and spatial distribution, the characteristics of changes and their mechanisms of high sea winds in the two oceans and one sea region. So, it is urgent to use new high-resolution data for in-depth research, but at present, there are relatively few comparative studies between ERA5 reanalysis surface winds and the observation data. Therefore, this paper compares the ICOADS moored buoy observation data with the ERA5 reanalysis data in the two oceans and one sea region, and the results show that the ERA5 reanalysis 10 m winds can well reflect the distribution and variation characteristics of sea surface wind field. In addition, the ERA5 reanalysis data has high temporal and spatial resolution, long time-series and complete data records. Using the ERA5 reanalysis data is feasible and has certain advantages for climate analysis of high sea winds. However, it should be noted that the ERA5 reanalysis surface wind speed generally has a systematic bias of underestimating the observed wind speed. In particular, the greater the observed wind speed, the greater the deviation of ERA5 from the observed wind speed.