Disconnection between scientific research and operational application has already become an important factor in restricting the transformation of scientific achievement on weather forecast into prediction capacity. On the basis of statement about the necessity of mechanism construction of combination of research and operation (CRO) on weather forecast, current situation at home and abroad, results and experiences of mechanism construction in National Meteorological Centre, China Meteorological Administration (CMA), are presented. After analyzing the problem of CRO mechanism, strategies and proposals are put forward. In addition, special work mechanism about ‘small entity, big network’, selection, admittance, transformation and qualification mechanisms of scientific achievements, scientific research mechanism coming from operation requirement are established so as to ensure the work about CRO put in effect successfully in the CMA Testbed and Proving Ground for Weather Forecast (TPGW).