This article gave out the diffusion calculation model of different seeding ways such as antiaircraft gun, rocket and plane, based on the analytical solution of cloud seeding diffusion in clouds, and studied the diffusion regularity and effective range of different seeding ways. Farthermore, the paper examined the calculation scheme by using a flight seeding track caught by satellite, and discussed the problems such as adequate seeding flight designing. The main conclusions are as follows: Taking antiaircraft gun as point source, and using single antiaircraft gun for work, the operation range is found to be only 0.5 km. So, it would be better if we take multi shell for work to keep concentration and diffusion range, and the result can be improved largely when nucleation rate is raised. The works of rockets and planes are regarded as line sources. The widths beyond threshold value one hour after seeding are 7 km and 6.6 km, which can be taken as the basis of multi line seeding flight interval. Single line seeding cannot reach the requirement of sufficient catalyzing. Impacted by winds, the diffusion area would disperse or overlap when using ‘S’ seeding way. So, the ‘8’ form flight route design based on wind velocity can make the target area get adequate seeded. The cloud seeding diffusion calculation and work designing software developed based on diffusion calculation model are convenient to calculate the diffusion range, concentration and evolution by using plane, antiaircraft gun and rocket in real operations. Besides, it is effective in designing the seeding ways for different target areas, and the results are direct and clear, offering assistance for actual operational application and seeding designing of diffusion calculation.