Based on Zhang Shuyu’s research (2013), the impact of cold wave on hypertension disease is preliminarily discussed through the animal experiments. The cold wave process is simulated in the environmental test chamber (TEM1880). At the same time, 27 healthy rats are randomly divided into the control group, 3 hours before Tmin (minimum temperature) group, 1 hour before Tmin group, Tmin group, 1 hour after Tmin group, 3 hours after Tmin group, cold wave process group, 5 hours after the cold wave process group, 7 hours after the cold wave process group, respectively. Each group has 3 rats. All the groups except the control group are exposed to the cold environment and taken out in accordance with the developing progress of cold wave respectively. The following indexes are measured: systolic blood pressure (SBP), heart rate (HR), weight, blood lipid, noradrenaline (NA), angiotensin Ⅱ (Ang Ⅱ), whole blood viscosity (WBV), etc. The experimental results show that the air temperature decreases rapidly under the control of the high pressure after cold front leaves in the cold wave process. WBV, NA and Ang Ⅱ can rise to the maximum value at the Tmin, making blood pressure increase in experimental rats in the whole time, and are hard to return to the original level even after the cold wave.