Based on the clinical data of Jilin Province several hospitals and the corresponding meteorological data, this study has analyzed the relationship between CVD(cardiocerebral vascular disease) and the weather conditions in Jilin Province. Results show that the recurrence and the aggravation of CVD have a certain relationship to the weather conditions, and different patients have different sensitivities to the weather changes. Among all the weather conditions, the impact of low air pressure and feeling of sultriness over the CVD are the most significant, with a confirmation rate of 74%. Whether in winter half year or summer half year, in Changchun City, both the sharp changes in air pressure and temperature are prone to cause coronary heart disease relapse, the relatively huge rise of air pressure and fall of air temperature are unfavorable to cerebral hemorrhage and cerebral infarction, a〖JP2〗nd the high blood pressure is mainly related to air pressure fluctuations and relatively humid weather. In Liaoyuan City, the incidence of CVD increases along with the falling of average daily temperature, dropping of extreme temperature and rise of air pressure. Through the analysis of meteorological factors in the development of CVD, we also found that hightemperature and high humidity weather can lead to the increase of cardiac output and cardiac load, eventually result in the falling of cardiac function. Besides, strong temperature drop can cause the rise of body’s adrenaline level, resulting in accelerated heart rate and blood pressure, and the stimulation of coldness can induce the overexcitement of sympathetic nerve, producing coronary spasm or even myocardial infarction. Finally, the medical weather forecasting model was established in Changchun and Liaoyuan City.