Immune allergy reaction of the sensitive population, which is a common and frequently occurring illness, is induced by the pollen granules floating in the lower atmosphere. The increment of urban afforestation ratio aggravates the disease dramatically during recent years. The prediction model of the pollen concentration for the future 1-4 days of different stations (it is above the 0.01 significance level of Ftest) is established by using the 1999-2005 (1 March to 30 September) daily data of monitoring pollen concentration in the lower atmosphere and the simultaneous surface meteorological data at 7 stations in Beijing and surrounding regions through the orthogonal selection regression method. The model was tested well and it can be used to the environmental meteorological service platform on trial, and provide prediction and prevention services (such as medication in advance) to the sanitary and epidemic institutions in the capital hospital and the patients as well.