With the development of wind electricity, wind resource simulation over complex terrain is becoming an important question for discussion. On the basis of wind o bservational data of one year of 9 observation towers at 22 levels in the southe rn zone of a certain coastal island of Guangdong Province, and the digital terra in data with high resolution of the island ,wind resource microscale simulatio n by multiple regression was done. In addition, the simulated result was compare d with that obtained by WASP program. It was found that:(1) There is a significa nt correlation between annual mean wind speed and geographical spatial factors;( 2) The mean relative errors of simulated annual mean wind speed and wind power d ensity are 3.2% and 3.5%, respectively; (3) The assumption test shows that there is a good effect in annual mean wind speedsimulation at those sites without observational data;(4) The distribution of th e wind resource is basically consistent with that obtained by WASP program.