With the daily surface meteorological elements which are classified statistically in past years from three stations in Guizhou, both the moving rule of the air mass effecting Guizhou area, and the correlation between the meteorological disaster and air mass motion frequency are analysed. The results show that the climate in Guizhou is effected by much air masses′ motion, and each has its corresponding weather characteristics. Additionally, the climate disaster is better related to some air masses′ change, which has much realism in the study of the climate change and the cause of formation of air mass in Guizhou.