A forecast method of mid- and long-term cold wave in Guangdong which based on the similar theory are introduced 11 key--regions in Northern Hemisphere connected closely with cold airactivities in Guangdong are choosed. Then weather information in each region are analyzed andextracted by using 500hpa pentad grid data. Finally the cold wave forecast,which based on dailytemperature at some stations of Guangdong,are made though comparison with the historical analogue examples.